You may have heard of PRP. Platelet-rich plasma has been a buzzy treatment in aesthetics for years now, and it’s still on the rise. Regenerative medicine is one of the fastest-growing segments of the aesthetic industry.
If you’ve looked into PRP and thought that sounds interesting, but is there something even better? you may be interested in SELPHYL® PRFM.
SELPHYL PRFM (platelet-rich fibrin matrix) has many of the same benefits as PRP and improves on its biggest limitation: how quickly it wears off.
At Brandilyn’s Aesthetic Boutique in Newnan, GA, nurse practitioner Brandilyn Johnson uses the SELPHYL system to convert your platelets into a longer-acting fibrin matrix that keeps delivering growth factors to your skin for days after treatment. Below, we will explore what Selphyl PRFM is, how it works, which conditions it can treat and what results you can expect.
What Is SELPHYL PRFM?
SELPHYL PRFM is an advanced regenerative treatment derived from your own blood. PRFM stands for platelet-rich fibrin matrix. It builds on what makes platelet-rich plasma effective by stabilizing the platelets within a fibrin scaffold, allowing the growth factors they contain to release over time rather than all at once.
This controlled release is what makes SELPHYL PRFM different. Instead of delivering a short burst of activity like standard PRP, PRFM provides extended support for tissue repair and collagen production.
What Makes PRFM Different From PRP?
PRP and PRFM treatments start the same way: with a small blood draw from your arm, similar to what you’d need for routine lab work. That blood gets spun in a centrifuge to separate platelets and plasma from other blood components.
After this first step, the treatments diverge. With standard PRP, the concentrated plasma is injected directly. Your platelets release their growth factors in a rapid burst, which is beneficial but short-lived.
PRFM adds a critical step to the treatment process. The platelet-rich plasma is transferred into a second tube containing calcium chloride, which triggers the formation of a fibrin scaffold. Over about 20 minutes, the liquid PRP transforms into a gel-like matrix that holds your platelets in place. After it’s injected, growth factors release steadily over days, giving your tissue sustained regenerative signals that support collagen production more effectively.
The SELPHYL system removes red and white blood cells during processing, which produces a purer product with less inflammatory potential. It’s also a closed system, meaning your blood never contacts outside air or equipment during preparation.
PRP vs. PRFM: Compare the Differences at a Glance
If you’re a visual person, here’s how the two treatments compare side by side:
| Traditional PRP | SELPHYL PRFM | |
| Source | Your own blood | Your own blood |
| Processing | Single centrifuge spin | Centrifuge spin + fibrin matrix conversion via calcium chloride |
| Growth Factor Release | Rapid burst (hours) | Gradual, sustained release (days) |
| Purity | Contains some red and white blood cells | Red and white blood cells removed for a purer product |
| System | Varies by provider; open or closed systems | Closed, standardized SELPHYL system |
| Typical Sessions Needed | Often requires more frequent treatments | Fewer sessions required due to prolonged activity |
| Best For | Mild skin rejuvenation, hair restoration support | Skin texture, fine lines, under-eye hollows, acne scars, subtle volume loss |
What Are the Benefits of SELPHYL PRFM?
These are a few reasons our patients are excited about PRFM and regenerative aesthetic treatments:
Natural and Autologous Treatment
Because PRFM is derived from your own blood, the risk of allergic reaction is minimal. The treatment works by enhancing your body’s natural healing processes.
Minimal Downtime
Most patients return to normal activities shortly after treatment. Mild swelling or redness may occur but typically resolves quickly.
Longer-Lasting Results
PRFM’s fibrin matrix allows growth factors to be released over time, supporting more sustained improvements compared to traditional PRP.
What Can SELPHYL PRFM Treat?
SELPHYL PRFM is used to improve skin quality and support natural regeneration in a variety of treatment areas. It is commonly used to improve overall skin quality, including tone, texture, firmness and damage that has occurred due to sun exposure. It’s also effective for softening fine lines, smoothing acne scarring, restoring subtle volume and refining lip definition.
Under-eye rejuvenation is one of the standout applications . The skin beneath your eyes is delicate and notoriously tricky to treat. PRFM works well in this area because it strengthens your skin from within rather than adding volume underneath the fragile tissue. Patients often notice improved hydration, less visible hollowing and a brighter, less tired appearance over the weeks that follow.
What Are the Steps of a SELPHYL PRFM Treatment?
The SELPHYL PRFM process includes four main steps:
Step One: Blood Draw
A small blood sample is collected into a vacuum-sealed tube containing a separation gel. This step helps preserve the sample’s integrity.
Step Two: Centrifugation
The blood is placed in a centrifuge and spun for six minutes. This separates the platelets and plasma from red and white blood cells.
Step Three: PRFM Formation
The platelet-rich plasma is transferred into a second tube containing calcium chloride. This triggers fibrin formation. Over the next 20 minutes, PRP transforms into PRFM, creating a matrix that stabilizes platelets and extends their activity.
Step Four: Injection or Application
Once prepared, the PRFM can be injected or topically applied based on the treatment plan.
Do SELPHYL PRFM Treatments Hurt?
Most patients tolerate the treatments well. If you’re concerned about the blood draw, know that it’s a small sample, comparable to what you’d give for routine bloodwork. The rest of the preparation happens outside your body.
When it’s time for injections, Brandilyn uses a fine needle similar to those used for Botox or filler treatments. A topical numbing cream can be applied beforehand if you’re sensitive, but most patients find the discomfort minimal.
Afterward, you might see mild redness or slight swelling at the injection sites that typically resolves within a day. Most patients go right back to their afternoon.
What Results Can You Expect From SELPHYL PRFM?
Results from SELPHYL PRFM develop gradually because it works by stimulating your body’s own collagen production mechanism. You may begin to notice changes in skin texture and tone within two to three weeks, with the most visible improvements appearing at the two- to three-month mark.
Most patients benefit from two to three sessions spaced a few weeks apart, though the exact number depends on what you’re treating and how your skin responds to the treatment. Results can last many months, and maintenance sessions once or twice a year can extend the benefits further.
Is SELPHYL PRFM Right for You?
If you’re noticing dullness, uneven texture, early fine lines, under-eye hollowing or mild volume loss and you like the idea of a natural, regenerative treatment, PRFM is worth a look. It also deserves consideration if you’ve tried PRP before and liked the concept but felt the results faded too quickly.
The best way to find out what your skin needs is a consultation where Brandilyn can assess you in person and map out a plan.
Discover a More Natural Approach to Skin Rejuvenation With SELPHYL PRFM
To book your SELPHYL PRFM consultation at Brandilyn’s Aesthetic Boutique in Newnan, GA, reach out online or call 770-755-6610. We also invite you to check the specials page or inquire about our membership program for ways to make your treatments more accessible.
